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28 A 24-week multinational, placebo-controlled, randomized, double-blind, parallel-group study was conducted to evaluate the efficacy and tolerability of sitagliptin when added to long-acting, intermediate-acting, or premixed insulin alone or in combination with metformin in patients with type-2 diabetes
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The ERK family includes two isoforms, ERK1 (44 kDa) and ERK2 (42 kDa) (67), both of which are activated by MEK, a key upstream kinase that phosphorylates threonine and tyrosine residues on ERK (68)
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PMID: 16144956
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