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For evaluation of varenicline as a pharmacotherapy option for smoking cessation in smokers with mental illness, 15 articles (13 RCTs) were selected from a previous systematic review and updated evidence and included for data synthesis.16, 17, 21, 30, 36, 40, 44, 51, 55, 56, 470, 471, 472, 473, 474 The results indicated that varenicline was significantly more effective than placebo in achieving smoking cessation at six months or longer (RR, 2.17

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Any legislation will allow for a buffer period of at least 6 months, to allow businesses to adapt