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As understanding of ferroptosis mechanisms deepens and multidisciplinary innovations progress, a multifaceted approach to targeting ferroptosis may ultimately emerge as a breakthrough for OA management by delaying disease progression and enhancing patients quality of life

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However, the reaction is kinetically driven in the forward direction by the removal of GS through the following reactions with thiolate anion (GS - ) and then with oxygen

J Chem Inf Model 59(8):34003412 Kirchmair J, Williamson MJ, Tyzack JD et al (2012) Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms