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Lung Res

Step 6: estimating the mean risk function and the BPRF In the final step, step 6, the metaregression model inclusive of the selected bias covariates from step 3 (for example, the highest adjustment level) was used to predict the mean risk function and its 95% UI, which incorporated the uncertainty of the mean effect, between-study heterogeneity and the uncertainty in the heterogeneity estimate accounting for small numbers of studies

doi:10.1016/S0007-0971(81)80009-5

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Multiply research groups have reported an alteration of immunophenotypes of macrophages toward M2 phenotype in COPD subjects, with cytokine production skew toward an M2 profile in blood and BAL samples from patients, suggesting M2 macrophages phenotype is a critical player in COPD disease progression (5052)