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Inactivation of hepatic foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

Before starting Tirzepatide, it is essential to have a thorough consultation with a healthcare provider to determine if it is the right option based on individual health history and weight loss goals

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Incorporating NET biomarkers into clinical protocols could enable patient stratification and guide targeted NET-modulating therapiessuch as PAD4 inhibitors, DNase, or antioxidantsin combination with standard-of-care interventions, ultimately improving metabolic and reproductive outcomes