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In the UK, there are several licensed GLP-1 medicines including semaglutide (sold under the brand names Wegovy, Ozempic and Rybelsus), tirzepatide (Mounjaro) and liraglutide (sold under various brand names)

Stacking simply means using more than one therapy at the same time to create a synergistic effect

Split-dose microdosing: an alternative approach Instead of one weekly injection at a very low dose, some protocols divide the weekly amount into two or three smaller injections given on different days

While no FDA-approved tapering protocol exists, structured approaches involving alternative therapies, lifestyle intensification, and close monitoring optimize outcomes