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Proposed Mechanisms of Action The pathways by which cigarette smoking exerts opposite effects in CD and UC are hard to establish, due to the large number of components in the smoke and the diverse cellular and tissue functions that may be affected, such as the mucosal barrier, gut microbiota, immune system, microvasculature, and others
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Thankfully, smoking cessation can reverse those changes
Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations
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