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KPV is not FDA-approved for any indication
The residues that coordinate Na + are unchanged in position, however the density for Na + is slightly weaker, and there is no density for the axial (basal) water molecule as described for the occluded conformation
published in the American Journal of Physiology-Endocrinology and Metabolism (2014) is an important dataset
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Because of several limitations in the existing literature, future research should focus on large-scale clinical trials with adequate design, sample size, elimination of biases, reporting of adverse events, and standardization of treatment outcomes
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