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Dendritic spine anomalies and PTEN alterations in a mouse model of VPA-induced autism spectrum disorder

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As an example, we have previously shown that adenovirus-mediated induction in human adult OLs of low levels of p53, a transcription factor that regulates apoptosis and can be detected in OLs in actively demyelinating MS lesions, renders these cells susceptible to subsequent FasL- and TRAIL-medicated killing 45

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Camini CF, da Silva Caetano CC, Almeida TL, de Brito Magalhaes LC

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