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Each step has a strong genetic component (for example, twin-based heritability estimates up to 70% for the transition from regular smoking to ND 3,4 ) and partial overlaps are expected among the sets of sequence variants correlating with the different stages 3 , as evidenced by findings of the GWAS and Sequencing Consortium of Alcohol and Nicotine use (GSCAN) with sample sizes up to 1.2 million individuals 5