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Margin of Exposure (MOE) calculation for synthetic cooling agents MOE, a preferred risk assessment parameter for toxic compounds by the JECFA 34 , 35 , was calculated for WS-3 and WS-23 containing E-liquids using the following formula, as described previously: 36 Where NOAEL is the No-Observed-Adverse-Effect-Level, a dose determined as the threshold producing a toxic effect in animal oral toxicity studies