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Other factors include, but are not limited to: 1 Age nicotine clearance decreases with age Sex studies have found women metabolize nicotine and cotinine faster than men Estrogen hormones there is a strong relationship between high estrogen levels, observed in premenopausal women, and increased metabolism of nicotine Smoking tobacco itself can also impact how long nicotine stays in your system

doi: 10.1186/s12889-021-10872-z

Carcinogenesis 37 , 269279 (2016)

HDL helps to clear bad cholesterol out of the system, so lower levels of it further increase the risk of harmful build-up