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It apparently promotes liver cell protein synthesis and decreases the oxidation of glutathione

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Moreover, in other separate studies, there was counteraction of the brain [83], spinal cord [35,36], heart failure [84], lung [41,85,86,87], liver lesions [88,89,90], liver, gastrointestinal and brain lesions [91,92,93,94,95,96], and kidney [97,98,99] and pancreas [100,101] lesions

Lenzini et al

1998) analyzed CYP2A5 expression in C3H, C57BL/6, and B6C3F1 mice and found expression in phenobarbital promoted preneoplastic and neoplastic liver lesions in all three strains