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Once addiction takes hold, users find themselves compelled to use nicotine to avoid withdrawal symptoms and to maintain the pleasurable effects, creating a reinforcing cycle of dependence

The first is that people who used e-cigarettes while still smoking didnt reduce the levels of toxic chemicals they were exposed to

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Additionally, that tarry goo that builds up over time can actually be detrimental to your health, and smoking it often causes headaches and other undesirable side effects

However, we now have reasonable epidemiological evidence in humans that lessens the impact of the Authors findings in rodents