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Glutathione mainly supports skin health from within through antioxidant activity, while glycolic acid works on the skin surface by exfoliating dead skin cells

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As noted by Akbarzadeh et al

Androgen regulation of spermidine synthase expression in the rat prostate

For example, the Carotene and Retinol Efficacy Trial (CARET), a study of beta-carotene and retinyl palmitate supplementation, was stopped prematurely due to an increase in lung cancer risk and death from lung cancer in participants who received the intervention [109]