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semaglutide from their respective phase III clinical trial programs in T2D revealed that, although there is a greater variability in semaglutide plasma concentrations following daily oral administration, this does not impact efficacy response

However, because Hashimoto's is an autoimmune condition and semaglutide affects metabolism and the gut, it is vital to work closely with your GP

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Two randomized control clinical trials reported conflicting effects on bone mineral content (BMC) and bone mineral density (BMD): one trial demonstrated preservation of BMC with GLP-1 use, while the other found no significant difference in BMC or BMD between treatment and control groups

I may also recommend checking for hormone imbalances or other medical issues that can slow progress, such as pursuing EvexiPEL hormone therapy for those experiencing fatigue or weight gain