Research by Wang et al
Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits -glutamylcysteine synthetas (-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc system) [126, 127]
Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation
DSIP Delta sleep inducing peptide DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide that plays a critical role in regulating sleep cycles, reducing stress, and modulating neuroendocrine function
On the other point, on the CTX itself, we placed a 15 l CTM drop of washed worms (100200, Appendix Fig S7)