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Given the increased choice and availability of therapies with differing mechanisms of action, it may be surmised that for patients who continue smoking (i.e., failing efforts at cessation as is often encountered) there may be a preferred treatment option given a potential differential impact (positive, negative, or neutral) of smoking on individual treatments

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Above all, I used to be a smoker too

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But Joel, we said, you pulled the plug on a product that was moving 105 million in its last year