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Although the pathomechanism underlying the relationship between acute OM and CS exposure remains unknown, previous studies have suggested that CS upregulates VEGF levels in the lower airways of the rat and human fetal lung, showing correlations with HIF-1 levels 28,29

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For heavy smokers or those who want maximum simplicity, cigalike devices that closely resemble traditional cigarettes in size and appearance often provide the smoothest transition

10.1093/toxsci/kfab062 9 DIN (2021)

adults who currently smoke cigarettes, another 23% say they previously smoked cigarettes on a regular basis