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That cross-substance signal points to a shared biology underlying addiction, and it opens the door to a fundamentally different approach: not treating one addiction at a time, but targeting that common biologic signal, that common craving across addictions

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Moreover, evidence indicates that e-cigarettes weaken the immune system, as exposure has been shown to induce altered immune response and homeostasis [141, 142] with significant disruptions specifically associated with fourth-generation e-cigarettes [143]