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Though evidence currently favors to the role of thiocyanate as the predominant thyroid suppressor, multiple other components of smoke, like hydroxypyridine metabolites and benzpyrenes, are also being researched for their potential to interfere with thyroid function.[] 2,3-hydroxypyridine have been found to inhibits thyroxin deiodination by reducing iodothyronine deiodinase activity.[] Several other mechanisms have been forwarded to explain the effect of tobacco smoke on thyroid

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