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The likelihood of experiencing adverse reactions generally increases at higher doses of these compounds

Orforglipron, based on trial experience, may feel rougher for sensitive GI systems, likely related to its pharmacology and rapid absorption, so if your top priority is gut calm, it may not be your first pick once available

To put this into context, a 100 kg (220-pound) person could shed 33 to 38 kg with retatrutide

The results are on par with bariatric surgery, which helps people lose on average 25% to 35% of their total body weight within one to two years

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