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These factors include: heavy alcohol use smoking or using tobacco products contracting certain strains of the human papillomavirus (HPV), including strains 16 and 18 prolonged exposure to natural or artificial sunlight, such as from tanning beds having undergone hemopoietic stem cell transplant The Other signs and symptoms of lip cancer may include: a lump on the lips or a noticeable thickening painful or numb lips bleeding from the lips a red or white patch on the lips tightness in the jaw that results from swelling As with other types of cancer, lip cancer may not always have obvious symptoms in the early stages