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The ADRs included myotoxicity and hepatotoxicity, where myotoxicity constituted a majority of the events

Weight Loss Efficacy (Phase 2, 48 Weeks) * Retatrutide: Mean body weight reduction up to 24.2% * Eloralintide: Mean body weight reduction up to 20.1% Both agents place themselves among the most potent obesity therapies currently in clinical development

It remains however to be proven to which extent these described mechanisms are related to the modest blood pressure decrease observed in humans and whether they contribute to stroke prevention

Exercise is important for health but its not the answer to losing weight

If further glycemic control is needed, doses can be increased after at least four weeks at the previous level