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May 2020;34(5):1114-1122

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Infants born to HBsAg-positive mothers are at risk of being infected with hepatitis B virus and becoming chronic carriers.(6,9-11) This risk is especially great if the mother is HBeAg-positive.(13-15) For an infant with perinatal exposure to an HBsAg-positive and HBeAg-positive mother, a regimen combining one dose of Hepatitis B Immune Globulin (Human) at birth with the hepatitis B vaccine series started soon after birth is 85%95% effective in preventing development of the HBV carrier state.(9,15) Regimens involving either multiple doses of Hepatitis B Immune Globulin (Human) alone or the vaccine series alone have 70%90% efficacy, while a single dose of Hepatitis B Immune Globulin (Human) alone has only 50% efficacy.(9,16) Sex partners of HBsAg-positive persons are at increased risk of acquiring HBV infection

The purpose of the following review is to present the most recent advances in the physiological, immunological, and therapeutic properties in patients with nonalcoholic fatty liver disease and NRF-2

184 and the specific considerations of OECD Users' handbook supplement to the guidance document for developing and assessing AOPs (no