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When stimulated simultaneously, the two receptors produce a synergistic GH pulse that substantially exceeds what either compound generates alone an effect documented in the broader GHRH + GHRP literature going back to the 1990s

European Journal of Endocrinology, 1998, 139(5):552-561

Weeks 5 to 12: Measurable reduction in subcutaneous fat, especially in stubborn areas like lower abdomen and flanks

IGF-I/IGF-IR actions in bone remodeling Throughout life, bone is constantly remodeled by co-operative actions of bone-resorbing osteoclasts and bone-forming osteoblasts (48,49)