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Indeed, NRF2 can bind to the promoter regions of pro-inflammatory cytokines (e.g., IL-6 and IL-1), preventing the recruitment of RNA polymerase II and thus inhibiting their gene transcription (Kobayashi et al

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Changes in blood glucose and lipids indicate a metabolic shift (405, 406, 410, 411) as there are reduced levels of acyl-carnitine and fatty acids (412), and amino acids from the urea cycle (187, 408)