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Glaviano A, Foo ASC, Lam HY, Yap KCH, Jacot W, Jones RH, et al

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Preclinical studies further highlight promising antitumor activity and targeted delivery potential for BA derivatives such as BANB6, BAMETUD2, and BAMETR2, as well as for the dual receptor agonist INT767 (176179)

This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis

Listeria monocytogenes and Salmonella Typhimurium manipulate NLRP3 inflammasome activity through mitochondrial perturbations