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In the STEP TEENS trial, nearly three-quarters of participants improved their BMI category by at least one level, and over 40% reached a BMI below the obesity threshold ( Safety data in youth are generally reassuring but incomplete

221,222 Activation of Akt stimulates -cell proliferation, reduces apoptosis, and enhances insulin secretion by regulating downstream effector molecules like Forkhead box protein O1 (FoxO1) and the glucose transporter type 2 (GLUT2)

Persistent vomiting requiring medical intervention affected approximately 2-3% of patients