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Except for reusable mailpieces that originate as permit imprint mailings, the piece must meet these standards: Basic Design

Environ Sci Pollut Res 10:235244 Wright SL, Rowe D, Reid MJ, Thomas KV, Galloway TS (2015) Bioaccumulation and biological effects of cigarette litter in marine worms

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Hepatotoxicity (liver cell damage), including elevated liver enzymes and jaundice, has been observed at intakes as low as 750 mg/day of nicotinic acid (128)

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