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The metformin binding to plasma proteins is negligible and it is eliminated unmodified by active tubular secretion and glomerular filtration (Scheen, 1996), thus is contraindicated in patients with kidney failure (Contraindications can damage your health--is metformin a case in point?, 2024)
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South Koreas largest tobacco firm, KT&G, agreed on Wednesday to pull a controversial advertising campaign for its This Africa cigarettes that used monkeys in promotional materials
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