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Besides, it is important to consider that intestinal GLP-1 has a local concentration in the nM range (10100 pico moles per gram of tissue, see Figure 1), further advocating that the main action of this protein have evolved to be locally restricted

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It has been reported that the overexpression of hsa-let-7c can downregulate the renewal capacity of stem cells subsets, and the upregulation of expression of hsa-let-7c is related with the mechanism of GH/IGF-1 axis signaling pathway 16,17

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