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[91] When nicotine intake stops, the upregulated nicotinic acetylcholine receptors induce withdrawal symptoms

However, a 2015 report by Public Health England encouraged the medical licensing of e-cigarettes in the UK as nicotine replacement therapy, stating that the use of vaping is 95% safer than smoking and can help people to quit smoking and reduce their cigarette consumption even among those not intending to quit and rejecting other support. And research from Frances Health Barometer, which conducted telephone interviews with over 15,000 people, found that e-cigs could have helped several hundreds of thousands quit smoking, at least temporarily

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