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Notably, tobacco carcinogen exposure led to significant changes in the gut and lung microbiomes, particularly in species like Odoribacter , Alistipes , Akkermansia , and Ruminococcus , which correlated with LUAD development and immunotherapeutic response

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[49] This led the authors of the study to conclude that "inhalational exposures of cinnamaldehyde may increase the risk of respiratory infections in e-cigarette users." [49] Some e-liquids containing cinnamaldehyde stimulate TRPA1, which might induce effects on the lung