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[87] Michigan Department of Treasury, Michigan's Cigarette and Tobacco Taxes 2004, October 2005, 14

It is user-friendly, compatible with most standard cigarette tubes, and built with durable construction for long-term use

However, like any substance, it may carry certain risks depending on individual sensitivity, consumption pattern and ingested dose

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Similar findings confirmed that chronic exposure to ENDS vapor (four to fifteen months) with ranging nicotine concentrations (024 mg/ml) led to vascular dysfunction impacting both endothelial-dependent and endothelial-independent mechanisms [85]