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In an ongoing debate, two major sources have been proposed: de novo synthesis of Put-GABA by an aldehyde dehydrogenase 1a1 (Aldh1a1) dependent pathway and/or reuptake of extracellular GABA originating in other cells by the transporter GAT1 (Tritsch et al., 2014

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Moreover, in subgroup analyses of the controls, tirzepatide did not increase the risks of any of these cancers compared to placebo, insulin, or GLP-1RA (Table 3)