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Individuals who smoke even half a pack of cigarettes a day may [be at] increase[d] risk of having [peripheral arterial disease] by up to 50 percent. However, it is important to note that up to 40 percent of peripheral arterial disease patients are asymptomatic, often leaving the condition misdiagnosed
Additionally, it must be noted that both nicotine and by-products of TS and e-cigs such as polycyclic aromatic hydrocarbons are inducers of CYP1A2, hence deciphering their individual role in interaction with anti-psychotics can be beneficial for clinical translation (Zevin and Benowitz 1999
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Some brands even use their required legal sticker as the tamper evident seal by placing this label partially over the blunt tube and cork cap
