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Risk Factors: Some authors mentioned the relationship between leukoplakia and tobacco, alcohol, sanguinaria, ultraviolet radiation, trauma, betel quid chewing, genetic factors, mate tea, and microorganisms

Because of this, they tend to be used more by serious bodybuilders and athletes who have coaches and medical staff around them to assist with administration

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Therefore, a tobacco harm reduction risk assessment that would evaluate the toxicity of individual toxicants from e-cigarette aerosols or heat-not-burn smoke, and not consider the interactions or synergy between these chemicals, may overestimate the reduced harm of a tobacco product

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