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Tobacco nitrate is the precursor to nitrite in tobacco, and the latter reacts with tobacco alkaloids during curing and processing to produce tobacco-specific nitrosamines, arguably the most carcinogenic constituents occurring in relatively high quantities in unburned tobacco, including cigar tobacco

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The analysis, published in Nicotine and Tobacco Research in May 2020, also revealed that when the disease worsened, current or former smokers had more acute conditions or were more likely to die

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