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Tobaccos immediate effects on the brain and mental health include: Increased anxiety Mood swings and irritability Trouble focusing Disrupted sleep Persistent headaches The nicotine in tobacco creates a cycle of increased discomfort

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Two of the three RCTs (50, 51) reported no statistically significant differences in immune response biomarkers related to CV health between daily e-cigarette users and smokers, and the third (52) reported statistically significant lower white blood cells in daily e-cigarette users