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[22] observed that the GIP receptor contains a functional PPAR- response element in the promoter region of the gene in INS-1 cells

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67 Regarding aging, activating GLP-1R enhances insulin sensitivity and addresses age-associated IR, a critical factor in metabolic disorders such as T2D

Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue

The fundamental difference between these two compounds lies in their receptor targeting strategies