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10.1002/smll.202003646 Summary Keywords platinum, peripheral neuropathy, reactive oxygen species, mechanism, therapeutic agents, nanosystems Citation Hu X, Jiang Z, Teng L, Yang H, Hong D, Zheng D and Zhao Q (2021) Platinum-Induced Peripheral Neuropathy (PIPN): ROS-Related Mechanism, Therapeutic Agents, and Nanosystems
This catecholamine-mediated oxidative stress causes aberrant cell signaling, intracellular Ca 2+ overload, mitochondrial damage, inflammatory responses, and disruption of the extracellular matrix and lysosomes, which in turn triggers apoptosis in cardiomyocytes (159163)
Rayman, M
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