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Recent studies have revealed additional biological functions of ZHX2 where it acts as a significant transcriptional activator by promoting the expression of genes such as fructose-2,6-biphosphatase/6-phosphofructo-2-kinase 3 involved in glycolysis [54]

Nevertheless, evidence for alternative topical formulations beyond these established agents remains limited and heterogeneous, with few randomized trials to date and largely observational data

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238 Due to the high energy requirements, both cardiac and skeletal muscles are rich in mitochondria but also influenced by oxidant stress and high rates of fuel oxidation