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Journal of Biological Chemistry 280, 25571-25579CrossRefGoogle ScholarPubMed 38Tenhunen, R., Marver, H.S

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The reasons for a vitamin B12 deficiency are manifold: Unfavourable eating habits (for example fast food and convenience food), absorption disorders in older age, a strict vegetarian diet or certain intestinal diseases are frequent causes

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Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]