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In a phase 2 study in T2DM patients over 16 weeks, the highest dose of danuglipron administered twice daily (120 mg) resulted in an average HbA1c reduction of 1.2%, with an average weight loss of 4.2 kg [111]

Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A

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Some ways to reduce this, per Jillian: Start with lower doses (such as 2-3 grams/day) and slowly increase after 1-2 weeks, rather than a loading phase of higher doses (such as 20 grams)

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