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Beyond engaging canonical hypothalamic and hindbrain networks that control metabolic homeostasis, GLP1RAs recruit a discrete population of Glp1r -expressing neurons in the central amygdala, which selectively suppress the consumption of palatable foods by reducing dopamine release in the nucleus accumbens

Planned medical or surgical procedures if you are due to undergo surgery or an invasive procedure, inform both your trial team and the anaesthetic or surgical team

They actually enhance each others effectiveness

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While this can support weight loss, it can also lead to unintended gaps in nutrition