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Nature 472, 476480

Mechanism-based research considerations include: Altered methylation: NNMT inhibition affects SAM, a participant in many methylation reactions

2 Studies have shown that, in cancer-associated fibroblasts (CAFs), treatment with 5-Amino-1MQ not only modifies histone methylation patterns but also suppresses tumor-supportive metabolic functions

In this context, melittin has been shown to impede in vitro and in vivo HCC cell movement via lowering Rac1-dependent processes (Haque et al., 2023)

Summary Keywords gut microbiome, intermittent fasting, metabolome, caloric restriction, obesity, weight loss, gastrointestinal symptoms, protein pacing Citation Mohr AE, Jasbi P, Bowes DA, Dirks B, Whisner CM, Arciero KM, Poe M, Gu H, Gumpricht E, Sweazea KL and Arciero PJ (2022) Exploratory analysis of one versus two-day intermittent fasting protocols on the gut microbiome and plasma metabolome in adults with overweight/obesity