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iScience 27 , 109796 (2024)

Prokopidis K, Giannos P, Katsikas Triantafyllidis K, Kechagias KS, Mesinovic J, Witard OC, et al

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Individuals with pre-existing health conditions should exercise caution and consult with a primary care provider before starting treatment

Researchers at the University of Halle demonstrated that H89, a PKA inhibitor, could block retatrutide chronotropic effects but not those of isoprenaline (a beta-adrenergic agonist), confirming that retatrutide works through a distinct PKA-dependent mechanism rather than through the sympathetic nervous system