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These effects contribute to the medication's glucose-lowering and weight-reduction benefits by promoting satiety and reducing caloric intake, but they also account for the high incidence of gastrointestinal adverse effects

While this study did show lowered blood glucose levels, GLP-1RA treatment improved retinal thickness, morphology, and vasculature [82]

doi:10.1210/en.2009-1432 Teichman SL, Neale A, Lawrence B, et al

Subsequent reperfusion triggers an abrupt overproduction of ROS, including hydrogen peroxide, superoxide anion, hydroxyl radical, singlet oxygen, hypochlorous acid, and nitric oxide 33 , amplifying oxidative stress and aggravating tissue injury