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CatG activity was also found to cause dysfunction of ciliated cells and destruction of airway epithelium in patients with bronchiectasis, and activity correlated with disease severity (114)
The active thiols of GSDMD (Cys38/56/268/467) are susceptible to oxidative modifications that enhance caspase-1-mediated cleavage, linking mitochondrial ROS to inflammatory death (63)
Both complexes contain mTOR, GL (G-protein -protein subunit-like), mLST8 (mammalian lethal with SEC13 protein) and deptor (DEP domain containing mTOR interacting protein) [103, 105, 106]
doi: 10.1038/nm.3145 36 KoethRALam-GalvezBRKirsopJWangZLevisonBSGuXet al
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